The Forum for Youth Investment and the William T. Grant Foundation are pleased to submit the following recommendations to the Commission on Evidence-Based Policymaking. We are encouraged by the Commission’s potential to promote the use of research evidence in policymaking, and we offer these insights with the hope of helping the Commission make the most of its historic opportunity. These suggestions are drawn from our experience as conveners of a learning group of senior career staff and appointees in research offices focused on children, youth, and families within the U.S. Departments of Education, Labor, Justice, and Health and Human Services, as well as in the Corporation for National and Community Service and the National Science Foundation. These agencies invest in research and evaluation to build policy-relevant evidence and will likely be charged with implementing many of the Commission’s recommendations. They also have experience responding to similar challenges in the past. For these reasons, their insights may guide the Commission in developing a transformational set of recommendations.