Artificial Intelligence has the potential to amplify the efficiency in evidence-to-policy pathways and ensure that synthesised evidence is just-in-time at whatever time for an urgent decision in the policy processes. The cRhona application is a promise and reality to “clone” an evidence intermediary while integrating the latest Artificial Intelligence technologies to amplify their efficiency, accuracy, collaboration, coordination, and transparency. In the cRhona application, policymakers, evidence intermediaries, and domain experts collaborate and coordinate to ensure that the evidence synthesis is just-in-time when it is needed, comprehensive and high quality even in very urgent situations, e.g., less than 48 hours.